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Cell and molecular biology of colon cancer doi link for cell and molecular biology of colon cancer the volume begins with a description of cell types and possible lineage in the normal colon by colony a subject one would be hard pressed to find reviewed elsewhere especially in as incisive a manner . Sis of the molecular genesis of colon cancer four cen tral tenets concerning the pathogenesis of cancer have been established the first is that the genetic and epi genetic alterations that underlie colon cancer forma tion promote the cancer formation process because they provide a clonal growth advantage to the cells that acquire them. Encyclopedia of cancer third edition provides a comprehensive up to date overview of the multiple facets of the disease including research treatment and societal impact this new edition comprises 180 contributions from renown experts who present the latest in mechanisms hallmarks of cancer causes of cancer prevention and control diagnosis and therapy pathology and the genetics of . Volume 21 issue 5 september pages 233 235 299 molecular biology of colorectal cancer author links open overlay panel md robert gryfe phd bharati bapat md msc steven gallinger md phd carol swallow md mark redston md jean couture genetic alterations that allow transformed colorectal epithelial cells to escape cell cycle arrest or . Introduction colorectal cancer crc is the third most common cancer in the world with over 1 million cases diagnosed per year and it is the fourth most common leading cause of cancer related death accounting for 8 of all deaths from cancer 1 3given the significant incidence and mortality of crc tremendous efforts and resources have been dedicated to improve survival in patients